Drug interactions
Glyburide-metformin + Memantine
Severity: Minor
Glyburide-metformin and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is renally secreted by cationic transporters and may compete with metformin for tubular secretion, potentially raising levels of either drug. Clinical significance is expected to be small in patients with normal renal function.
What this interaction means in plain words
Glyburide-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Memantine belongs to Central Nervous System.
Why it happens
Competition for renal tubular secretion via organic cation transporters.
What to do
Monitor renal function and for adverse effects of either drug, especially in older patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Glyburide-metformin with Memantine?
MediHelp rates the interaction as minor. Glyburide-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is renally secreted by cationic transporters and may compete with metformin for tubular secretion, potentially raising levels of either drug. Clinical significance is expected to be small in patients with normal renal function.
How serious is the interaction between Glyburide-metformin and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for adverse effects of either drug, especially in older patients or those with renal impairment.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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