Drug interactions
Glyburide-metformin + Moxifloxacin
Severity: Moderate
Glyburide-metformin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause serious hypoglycemia or hyperglycemia in diabetic patients, especially those on sulfonylureas. Moxifloxacin carries a relatively lower dysglycemia risk than some other quinolones but it is still reported.
What this interaction means in plain words
Glyburide-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones block pancreatic beta-cell potassium channels, stimulating insulin release in addition to glyburide.
What to do
Monitor blood glucose during the antibiotic course and counsel the patient on hypoglycemia symptoms. Consider reducing the glyburide dose or choosing a non-quinolone in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Moxifloxacin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause serious hypoglycemia or hyperglycemia in diabetic patients, especially those on sulfonylureas. Moxifloxacin carries a relatively lower dysglycemia risk than some other quinolones but it is still reported.
How serious is the interaction between Glyburide-metformin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and counsel the patient on hypoglycemia symptoms. Consider reducing the glyburide dose or choosing a non-quinolone in high-risk patients.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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