Drug interactions
Glyburide-metformin + Omeprazole
Severity: Minor
Glyburide-metformin and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole may modestly increase glyburide exposure through effects on CYP2C9 metabolism, potentially increasing hypoglycemia risk. The effect is generally small.
What this interaction means in plain words
Glyburide-metformin and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole may weakly inhibit CYP2C9/CYP2C19-mediated metabolism of glyburide.
What to do
No routine dose change is needed; monitor for hypoglycemia when starting omeprazole in susceptible patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Glyburide-metformin with Omeprazole?
MediHelp rates the interaction as minor. Glyburide-metformin and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole may modestly increase glyburide exposure through effects on CYP2C9 metabolism, potentially increasing hypoglycemia risk. The effect is generally small.
How serious is the interaction between Glyburide-metformin and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for hypoglycemia when starting omeprazole in susceptible patients.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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