Drug interactions
Glyburide-metformin + Rosuvastatin
Severity: Minor
Glyburide-metformin and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may modestly increase rosuvastatin concentrations, which could raise the risk of statin-related muscle toxicity. The clinical impact is usually small, and the combination is common in diabetic patients.
What this interaction means in plain words
Glyburide-metformin and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Glyburide may inhibit hepatic OATP1B1 uptake of rosuvastatin, raising its plasma levels.
What to do
No routine dose change is needed. Ask patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Glyburide-metformin with Rosuvastatin?
MediHelp rates the interaction as minor. Glyburide-metformin and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may modestly increase rosuvastatin concentrations, which could raise the risk of statin-related muscle toxicity. The clinical impact is usually small, and the combination is common in diabetic patients.
How serious is the interaction between Glyburide-metformin and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Ask patients to report unexplained muscle pain or weakness.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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