Drug interactions
Glyburide-metformin + Sirolimus
Severity: Moderate
Glyburide-metformin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus causes hyperglycemia and insulin resistance and may impair glycemic control in patients taking glyburide-metformin. Higher antidiabetic doses may be needed.
What this interaction means in plain words
Glyburide-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition causes insulin resistance and reduced beta-cell function, opposing antidiabetic effects.
What to do
Monitor glucose and HbA1c after starting sirolimus and intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Sirolimus?
MediHelp rates the interaction as moderate. Glyburide-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus causes hyperglycemia and insulin resistance and may impair glycemic control in patients taking glyburide-metformin. Higher antidiabetic doses may be needed.
How serious is the interaction between Glyburide-metformin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting sirolimus and intensify antidiabetic therapy as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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