Drug interactions
Glyburide-metformin + Tacrolimus
Severity: Moderate
Glyburide-metformin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus commonly causes hyperglycemia and new-onset diabetes, which can offset the effect of glyburide and metformin. Tacrolimus nephrotoxicity may also reduce metformin clearance.
What this interaction means in plain words
Glyburide-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus impairs pancreatic beta-cell insulin secretion and increases insulin resistance, opposing antidiabetic drugs.
What to do
Monitor glucose and renal function regularly and adjust antidiabetic therapy. Reassess metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Tacrolimus?
MediHelp rates the interaction as moderate. Glyburide-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus commonly causes hyperglycemia and new-onset diabetes, which can offset the effect of glyburide and metformin. Tacrolimus nephrotoxicity may also reduce metformin clearance.
How serious is the interaction between Glyburide-metformin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function regularly and adjust antidiabetic therapy. Reassess metformin if renal function declines.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
