Drug interactions
Glyburide-metformin + Testosterone
Severity: Minor
Glyburide-metformin and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone can improve insulin sensitivity and lower blood glucose, which may enhance the effect of antidiabetic drugs. Hypoglycemia is possible, particularly with a sulfonylurea.
What this interaction means in plain words
Glyburide-metformin and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Androgen-related improvement in insulin sensitivity adds to the glucose-lowering of the antidiabetic agents.
What to do
Monitor blood glucose when starting or stopping testosterone and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Glyburide-metformin with Testosterone?
MediHelp rates the interaction as minor. Glyburide-metformin and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone can improve insulin sensitivity and lower blood glucose, which may enhance the effect of antidiabetic drugs. Hypoglycemia is possible, particularly with a sulfonylurea.
How serious is the interaction between Glyburide-metformin and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping testosterone and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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