Drug interactions
Glyburide-metformin + Torsemide
Severity: Moderate
Glyburide-metformin and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as torsemide may raise blood glucose and reduce the effect of antidiabetic drugs. Volume depletion and reduced renal function may also increase the risk of metformin accumulation.
What this interaction means in plain words
Glyburide-metformin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and reduced insulin secretion can raise glucose, and dehydration can impair metformin clearance.
What to do
Monitor glucose, potassium and renal function, and adjust antidiabetic doses as needed. Hold metformin if significant dehydration or renal impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Torsemide
Frequently asked questions
Can I take Glyburide-metformin with Torsemide?
MediHelp rates the interaction as moderate. Glyburide-metformin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as torsemide may raise blood glucose and reduce the effect of antidiabetic drugs. Volume depletion and reduced renal function may also increase the risk of metformin accumulation.
How serious is the interaction between Glyburide-metformin and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, potassium and renal function, and adjust antidiabetic doses as needed. Hold metformin if significant dehydration or renal impairment occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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