Drug interactions
Glyburide-metformin + Trimethoprim
Severity: Moderate
Glyburide-metformin and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim reduces the renal elimination of metformin, which raises metformin exposure. This may increase the risk of gastrointestinal effects and, in patients with renal impairment, lactic acidosis.
What this interaction means in plain words
Glyburide-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Trimethoprim inhibits renal tubular transporters OCT2 and MATE1/MATE2-K, which reduces the secretion of metformin.
What to do
Monitor renal function and glycemic control while the two drugs are combined, and reduce the metformin dose if needed. Avoid the combination in patients with reduced eGFR when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Trimethoprim
Frequently asked questions
Can I take Glyburide-metformin with Trimethoprim?
MediHelp rates the interaction as moderate. Glyburide-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim reduces the renal elimination of metformin, which raises metformin exposure. This may increase the risk of gastrointestinal effects and, in patients with renal impairment, lactic acidosis.
How serious is the interaction between Glyburide-metformin and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic control while the two drugs are combined, and reduce the metformin dose if needed. Avoid the combination in patients with reduced eGFR when possible.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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