Drug interactions
Glyburide-metformin + Voriconazole
Severity: Major
Glyburide-metformin and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits the metabolism of glyburide, raising its levels and the risk of prolonged or severe hypoglycemia. The effect is clinically relevant in patients with poor intake or renal impairment.
What this interaction means in plain words
Glyburide-metformin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide-metformin belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9 (and CYP2C19/CYP3A4), reducing glyburide clearance.
What to do
Monitor blood glucose closely and reduce the glyburide dose when starting voriconazole, or switch to an alternative agent. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Voriconazole?
MediHelp rates the interaction as major. Glyburide-metformin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole inhibits the metabolism of glyburide, raising its levels and the risk of prolonged or severe hypoglycemia. The effect is clinically relevant in patients with poor intake or renal impairment.
How serious is the interaction between Glyburide-metformin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glyburide dose when starting voriconazole, or switch to an alternative agent. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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