Drug interactions
Glyburide-metformin + Vorinostat
Severity: Moderate
Glyburide-metformin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat is associated with hyperglycemia, which may counteract the effect of antidiabetic drugs and worsen glycemic control. The interaction is a pharmacodynamic one and has been described mainly from labeling and clinical experience.
What this interaction means in plain words
Glyburide-metformin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Vorinostat can independently cause hyperglycemia, which opposes the effect of glyburide and metformin; the mechanism is not fully established.
What to do
Monitor blood glucose frequently during vorinostat therapy. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Glyburide-metformin with Vorinostat?
MediHelp rates the interaction as moderate. Glyburide-metformin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat is associated with hyperglycemia, which may counteract the effect of antidiabetic drugs and worsen glycemic control. The interaction is a pharmacodynamic one and has been described mainly from labeling and clinical experience.
How serious is the interaction between Glyburide-metformin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during vorinostat therapy. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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