Drug interactions
Glycopyrrolate + Ipratropium-salbutamol
Severity: Moderate
Glycopyrrolate and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ipratropium and glycopyrrolate are antimuscarinic agents, so combined use can add to anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and tachycardia. The effect is more relevant with systemic glycopyrrolate in older or susceptible patients.
What this interaction means in plain words
Glycopyrrolate and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive pharmacodynamic muscarinic receptor antagonism.
What to do
Monitor for anticholinergic adverse effects such as urinary retention, constipation, dry mouth and raised intraocular pressure. Reduce or stop one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Glycopyrrolate and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ipratropium and glycopyrrolate are antimuscarinic agents, so combined use can add to anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and tachycardia. The effect is more relevant with systemic glycopyrrolate in older or susceptible patients.
How serious is the interaction between Glycopyrrolate and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation, dry mouth and raised intraocular pressure. Reduce or stop one agent if symptoms develop.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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