Drug interactions
Glycopyrrolate + Loxapine
Severity: Moderate
Glycopyrrolate and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has anticholinergic activity that adds to glycopyrrolate. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and may worsen ileus in susceptible patients.
What this interaction means in plain words
Glycopyrrolate and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects at peripheral and central muscarinic receptors.
What to do
Monitor for anticholinergic toxicity such as constipation, urinary retention and overheating, especially in elderly patients. Reduce the glycopyrrolate dose or choose alternatives if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Loxapine?
MediHelp rates the interaction as moderate. Glycopyrrolate and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has anticholinergic activity that adds to glycopyrrolate. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and may worsen ileus in susceptible patients.
How serious is the interaction between Glycopyrrolate and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as constipation, urinary retention and overheating, especially in elderly patients. Reduce the glycopyrrolate dose or choose alternatives if symptoms develop.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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