Drug interactions
Glycopyrrolate + Maprotiline
Severity: Moderate
Glycopyrrolate and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline has appreciable anticholinergic activity, and glycopyrrolate is an antimuscarinic. Taken together they can intensify dry mouth, constipation, urinary retention, blurred vision and tachycardia, and may cause confusion in older patients.
What this interaction means in plain words
Glycopyrrolate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive peripheral and central antimuscarinic effects from two drugs that block muscarinic receptors.
What to do
Monitor for anticholinergic toxicity such as urinary retention, constipation, tachycardia and delirium, particularly in elderly patients. Reduce the dose or choose a non-anticholinergic alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Maprotiline?
MediHelp rates the interaction as moderate. Glycopyrrolate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline has appreciable anticholinergic activity, and glycopyrrolate is an antimuscarinic. Taken together they can intensify dry mouth, constipation, urinary retention, blurred vision and tachycardia, and may cause confusion in older patients.
How serious is the interaction between Glycopyrrolate and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, constipation, tachycardia and delirium, particularly in elderly patients. Reduce the dose or choose a non-anticholinergic alternative if symptoms develop.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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