Drug interactions
Glycopyrrolate + Memantine-donepezil
Severity: Minor
Glycopyrrolate and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil enhances cholinergic activity while glycopyrrolate blocks muscarinic receptors, so each can reduce the effect of the other. Glycopyrrolate acts mainly peripherally, so this may blunt donepezil's GI and cardiac effects, while central anticholinergic action is limited. The clinical outcome is variable.
What this interaction means in plain words
Glycopyrrolate and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrrolate belongs to Respiratory; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Monitor for loss of effect of either drug and for cholinergic effects such as bradycardia. Glycopyrrolate may be used deliberately to counter donepezil GI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glycopyrrolate and Memantine-donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Memantine-donepezil?
MediHelp rates the interaction as minor. Glycopyrrolate and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Donepezil enhances cholinergic activity while glycopyrrolate blocks muscarinic receptors, so each can reduce the effect of the other. Glycopyrrolate acts mainly peripherally, so this may blunt donepezil's GI and cardiac effects, while central anticholinergic action is limited. The clinical outcome is variable.
How serious is the interaction between Glycopyrrolate and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of effect of either drug and for cholinergic effects such as bradycardia. Glycopyrrolate may be used deliberately to counter donepezil GI adverse effects.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
