Drug interactions
Glycopyrrolate + Orphenadrin
Severity: Moderate
Glycopyrrolate and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combining them can intensify peripheral anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Patients with glaucoma, prostatic hypertrophy or ileus are at greater risk.
What this interaction means in plain words
Glycopyrrolate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity, especially urinary retention, constipation and heart rate, and lower doses or choose an alternative in at-risk or elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Orphenadrin?
MediHelp rates the interaction as moderate. Glycopyrrolate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combining them can intensify peripheral anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Patients with glaucoma, prostatic hypertrophy or ileus are at greater risk.
How serious is the interaction between Glycopyrrolate and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially urinary retention, constipation and heart rate, and lower doses or choose an alternative in at-risk or elderly patients.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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