Drug interactions
Glycopyrrolate + Thioridazine
Severity: Moderate
Glycopyrrolate and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine has substantial antimuscarinic activity, and glycopyrrolate adds to it. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, particularly in older patients.
What this interaction means in plain words
Glycopyrrolate and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and confusion, and reduce the dose or stop one agent if they develop. Be especially cautious in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Thioridazine?
MediHelp rates the interaction as moderate. Glycopyrrolate and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine has substantial antimuscarinic activity, and glycopyrrolate adds to it. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, particularly in older patients.
How serious is the interaction between Glycopyrrolate and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and confusion, and reduce the dose or stop one agent if they develop. Be especially cautious in older adults.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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