Drug interactions
Glycopyrrolate + Tiotropium
Severity: Moderate
Glycopyrrolate and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinics, so using them together duplicates anticholinergic activity. Oral or injected glycopyrrolate can add to systemic effects such as dry mouth, urinary retention, constipation and tachycardia.
What this interaction means in plain words
Glycopyrrolate and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Tiotropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid unnecessary combined use; monitor for urinary retention, constipation, tachycardia and eye symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glycopyrrolate and Tiotropium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tiotropium
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Tiotropium?
MediHelp rates the interaction as moderate. Glycopyrrolate and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinics, so using them together duplicates anticholinergic activity. Oral or injected glycopyrrolate can add to systemic effects such as dry mouth, urinary retention, constipation and tachycardia.
How serious is the interaction between Glycopyrrolate and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary combined use; monitor for urinary retention, constipation, tachycardia and eye symptoms.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
