Drug interactions
Glycopyrrolate + Umeclidinium-vilanterol
Severity: Moderate
Glycopyrrolate and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrrolate is an antimuscarinic, and umeclidinium is a long-acting antimuscarinic, so combined use duplicates therapy. This may increase dry mouth, urinary retention, constipation and tachycardia.
What this interaction means in plain words
Glycopyrrolate and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects from two anticholinergic agents.
What to do
Avoid the combination where possible; if glycopyrrolate is needed for another indication, monitor for anticholinergic effects and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Glycopyrrolate and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrrolate is an antimuscarinic, and umeclidinium is a long-acting antimuscarinic, so combined use duplicates therapy. This may increase dry mouth, urinary retention, constipation and tachycardia.
How serious is the interaction between Glycopyrrolate and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if glycopyrrolate is needed for another indication, monitor for anticholinergic effects and urinary retention.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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