Drug interactions
Glycopyrrolate + Ziprasidone
Severity: Minor
Glycopyrrolate and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has modest anticholinergic properties that may add to the effects of glycopyrrolate. This can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, particularly in older patients.
What this interaction means in plain words
Glycopyrrolate and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrrolate belongs to Respiratory; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive anticholinergic (antimuscarinic) pharmacodynamic effects.
What to do
Monitor for anticholinergic effects such as constipation, urinary retention and confusion, particularly in elderly patients. Reduce the glycopyrrolate dose if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Ziprasidone?
MediHelp rates the interaction as minor. Glycopyrrolate and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone has modest anticholinergic properties that may add to the effects of glycopyrrolate. This can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia, particularly in older patients.
How serious is the interaction between Glycopyrrolate and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation, urinary retention and confusion, particularly in elderly patients. Reduce the glycopyrrolate dose if they become troublesome.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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