Drug interactions
Glycopyrronium + Imipramine
Severity: Moderate
Glycopyrronium and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a tricyclic with considerable anticholinergic activity, so adding glycopyrronium increases dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Glycopyrronium and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity, especially in older patients, and lower doses or choose an alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Imipramine?
MediHelp rates the interaction as moderate. Glycopyrronium and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a tricyclic with considerable anticholinergic activity, so adding glycopyrronium increases dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Glycopyrronium and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients, and lower doses or choose an alternative if symptoms develop.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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