Drug interactions
Glycopyrronium + Nortriptyline
Severity: Moderate
Glycopyrronium and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline has appreciable anticholinergic activity, so combining it with glycopyrronium adds to antimuscarinic effects. Dry mouth, constipation, urinary retention, blurred vision and tachycardia may become troublesome, particularly in older patients.
What this interaction means in plain words
Glycopyrronium and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects at peripheral and central muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects such as urinary retention, constipation and tachycardia, and reduce doses or choose an alternative if they emerge. Take extra care in elderly patients and those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Nortriptyline?
MediHelp rates the interaction as moderate. Glycopyrronium and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline has appreciable anticholinergic activity, so combining it with glycopyrronium adds to antimuscarinic effects. Dry mouth, constipation, urinary retention, blurred vision and tachycardia may become troublesome, particularly in older patients.
How serious is the interaction between Glycopyrronium and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention, constipation and tachycardia, and reduce doses or choose an alternative if they emerge. Take extra care in elderly patients and those with glaucoma or prostatic hypertrophy.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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