Drug interactions
Glycopyrronium + Oxybutynin
Severity: Moderate
Glycopyrronium and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antimuscarinic agents, so their effects add together. This can produce marked dry mouth, constipation, urinary retention, blurred vision and tachycardia, and oxybutynin can also cause confusion in older adults.
What this interaction means in plain words
Glycopyrronium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Oxybutynin belongs to Genitourinary.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Avoid duplicating antimuscarinic therapy where possible; if both are needed, use the lowest doses and monitor for anticholinergic toxicity, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Oxybutynin
Frequently asked questions
Can I take Glycopyrronium with Oxybutynin?
MediHelp rates the interaction as moderate. Glycopyrronium and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antimuscarinic agents, so their effects add together. This can produce marked dry mouth, constipation, urinary retention, blurred vision and tachycardia, and oxybutynin can also cause confusion in older adults.
How serious is the interaction between Glycopyrronium and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating antimuscarinic therapy where possible; if both are needed, use the lowest doses and monitor for anticholinergic toxicity, especially in older patients.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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