Drug interactions
Glycopyrronium + Scopolamine
Severity: Moderate
Glycopyrronium and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic drugs, so combined use adds to dry mouth, blurred vision, constipation, urinary retention and tachycardia. Scopolamine crosses the blood-brain barrier and can cause drowsiness, confusion or delirium, particularly in older adults.
What this interaction means in plain words
Glycopyrronium and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Scopolamine belongs to Respiratory.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Avoid duplicate antimuscarinic therapy where possible; otherwise use the lowest effective doses and monitor for anticholinergic and CNS toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Scopolamine
Frequently asked questions
Can I take Glycopyrronium with Scopolamine?
MediHelp rates the interaction as moderate. Glycopyrronium and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic drugs, so combined use adds to dry mouth, blurred vision, constipation, urinary retention and tachycardia. Scopolamine crosses the blood-brain barrier and can cause drowsiness, confusion or delirium, particularly in older adults.
How serious is the interaction between Glycopyrronium and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antimuscarinic therapy where possible; otherwise use the lowest effective doses and monitor for anticholinergic and CNS toxicity.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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