Drug interactions
Golimumab + Influenza virus vaccine quadrivalent
Severity: Minor
Golimumab and Influenza virus vaccine quadrivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Golimumab, a TNF blocker, may blunt the antibody response to inactivated influenza vaccine, so protection may be reduced. Inactivated vaccines carry no infection risk and are recommended for patients on TNF inhibitors. The interaction is a reduced immunogenicity issue, not a contraindication.
What this interaction means in plain words
Golimumab and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF-alpha blockade causes immunosuppression that can modestly reduce vaccine-induced antibody responses.
What to do
Give the inactivated vaccine, ideally before starting golimumab or at any time during therapy, since the benefit outweighs the reduced response. Do not delay vaccination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as minor. Golimumab and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Golimumab, a TNF blocker, may blunt the antibody response to inactivated influenza vaccine, so protection may be reduced. Inactivated vaccines carry no infection risk and are recommended for patients on TNF inhibitors. The interaction is a reduced immunogenicity issue, not a contraindication.
How serious is the interaction between Golimumab and Influenza virus vaccine quadrivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine, ideally before starting golimumab or at any time during therapy, since the benefit outweighs the reduced response. Do not delay vaccination.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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