Drug interactions
Golimumab + Meningococcal group b vaccine
Severity: Moderate
Golimumab and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Golimumab, a TNF blocker, can blunt the antibody response to non-live vaccines such as meningococcal group B vaccine. Patients may therefore be incompletely protected after vaccination, although the vaccine is not unsafe.
What this interaction means in plain words
Golimumab and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF inhibition causes immunosuppression that may reduce vaccine-induced immune responses.
What to do
Where possible, give the vaccine before starting golimumab or at a time when the dose schedule allows. Do not delay vaccination in at-risk patients, and consider checking for protection or following local guidance on boosters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Golimumab and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Golimumab, a TNF blocker, can blunt the antibody response to non-live vaccines such as meningococcal group B vaccine. Patients may therefore be incompletely protected after vaccination, although the vaccine is not unsafe.
How serious is the interaction between Golimumab and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine before starting golimumab or at a time when the dose schedule allows. Do not delay vaccination in at-risk patients, and consider checking for protection or following local guidance on boosters.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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