Drug interactions
Golimumab + Methotrexate
Severity: Moderate
Golimumab and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, and combined use may increase the risk of serious infections. The combination is used therapeutically in rheumatoid arthritis, where methotrexate also reduces golimumab immunogenicity.
What this interaction means in plain words
Golimumab and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Golimumab belongs to Musculoskeletal; Methotrexate belongs to Oncology.
Why it happens
Additive immunosuppression from TNF-alpha blockade and methotrexate.
What to do
Screen for latent tuberculosis and hepatitis B before treatment, and monitor for signs of infection and blood count abnormalities during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Methotrexate?
MediHelp rates the interaction as moderate. Golimumab and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, and combined use may increase the risk of serious infections. The combination is used therapeutically in rheumatoid arthritis, where methotrexate also reduces golimumab immunogenicity.
How serious is the interaction between Golimumab and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for latent tuberculosis and hepatitis B before treatment, and monitor for signs of infection and blood count abnormalities during therapy.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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