Drug interactions
Golimumab + Muromonab cd3
Severity: Major
Golimumab and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining golimumab with the T-cell depleting antibody muromonab-CD3 produces profound combined immunosuppression. This raises the risk of serious opportunistic infections and possibly lymphoproliferative disorders.
What this interaction means in plain words
Golimumab and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from TNF blockade and T-cell depletion.
What to do
Avoid concurrent use where an alternative exists. If unavoidable, monitor closely for infection and consider antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Muromonab cd3?
MediHelp rates the interaction as major. Golimumab and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining golimumab with the T-cell depleting antibody muromonab-CD3 produces profound combined immunosuppression. This raises the risk of serious opportunistic infections and possibly lymphoproliferative disorders.
How serious is the interaction between Golimumab and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If unavoidable, monitor closely for infection and consider antimicrobial prophylaxis.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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