Drug interactions
Golimumab + Mycophenolate
Severity: Major
Golimumab and Mycophenolate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, and their combination increases the risk of serious bacterial, viral, fungal and opportunistic infections. Malignancy risk may also rise with prolonged combined exposure.
What this interaction means in plain words
Golimumab and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from TNF blockade and inhibition of lymphocyte purine synthesis.
What to do
Use together only when clearly justified and with the lowest effective doses. Screen for latent TB and hepatitis B beforehand and monitor for signs of infection; hold golimumab if serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Mycophenolate?
MediHelp rates the interaction as major. Golimumab and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, and their combination increases the risk of serious bacterial, viral, fungal and opportunistic infections. Malignancy risk may also rise with prolonged combined exposure.
How serious is the interaction between Golimumab and Mycophenolate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clearly justified and with the lowest effective doses. Screen for latent TB and hepatitis B beforehand and monitor for signs of infection; hold golimumab if serious infection develops.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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