Drug interactions
Golimumab + Ofatumumab sc
Severity: Moderate
Golimumab and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, so using them together may increase the risk of serious infections. Ofatumumab depletes B cells and golimumab blocks TNF, so effects on host defence add together.
What this interaction means in plain words
Golimumab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through B-cell depletion (ofatumumab) and TNF blockade (golimumab).
What to do
Avoid routine combination unless clearly justified; monitor closely for signs of infection. When switching, allow for the prolonged immune effects of the prior drug before starting the next.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Golimumab and Ofatumumab sc, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Ofatumumab sc?
MediHelp rates the interaction as moderate. Golimumab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress immune function, so using them together may increase the risk of serious infections. Ofatumumab depletes B cells and golimumab blocks TNF, so effects on host defence add together.
How serious is the interaction between Golimumab and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination unless clearly justified; monitor closely for signs of infection. When switching, allow for the prolonged immune effects of the prior drug before starting the next.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
