Drug interactions
Golimumab + Olaparib
Severity: Moderate
Golimumab and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and golimumab adds infection risk through immunosuppression. Together, the risk of serious infection in a neutropenic patient may be higher.
What this interaction means in plain words
Golimumab and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Golimumab belongs to Musculoskeletal; Olaparib belongs to Oncology.
Why it happens
Olaparib-induced myelosuppression combined with TNF-blocker immunosuppression, giving additive pharmacodynamic effects on infection risk.
What to do
Monitor blood counts regularly and watch for signs of infection. Interrupt or adjust olaparib per labeling if significant cytopenias develop, and reassess the need for golimumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Golimumab with Olaparib?
MediHelp rates the interaction as moderate. Golimumab and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and golimumab adds infection risk through immunosuppression. Together, the risk of serious infection in a neutropenic patient may be higher.
How serious is the interaction between Golimumab and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and watch for signs of infection. Interrupt or adjust olaparib per labeling if significant cytopenias develop, and reassess the need for golimumab.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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