Drug interactions
Golimumab + Rotavirus oral vaccine live
Severity: Major
Golimumab and Rotavirus oral vaccine live: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotavirus vaccine is live attenuated. Infants exposed to golimumab (including in utero or via breast milk) could be at risk of vaccine-strain infection, and the response may be reduced.
What this interaction means in plain words
Golimumab and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
TNF-alpha blockade impairs immune control of replicating live attenuated virus.
What to do
Avoid live vaccines in patients on golimumab; for infants with in utero exposure, follow labeling guidance on delaying live vaccines, typically for several months.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Rotavirus oral vaccine live?
MediHelp rates the interaction as major. Golimumab and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rotavirus vaccine is live attenuated. Infants exposed to golimumab (including in utero or via breast milk) could be at risk of vaccine-strain infection, and the response may be reduced.
How serious is the interaction between Golimumab and Rotavirus oral vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines in patients on golimumab; for infants with in utero exposure, follow labeling guidance on delaying live vaccines, typically for several months.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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