Drug interactions
Golimumab + Yellow fever vaccine
Severity: Contraindicated
Golimumab and Yellow fever vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated and can cause serious vaccine-associated neurotropic or viscerotropic disease in immunosuppressed patients such as those on golimumab.
What this interaction means in plain words
Golimumab and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF-alpha blockade impairs immune control of replicating live attenuated virus.
What to do
Avoid the vaccine during golimumab therapy; advise against travel to endemic areas or provide a medical exemption letter when appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Golimumab with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Golimumab and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yellow fever vaccine is live attenuated and can cause serious vaccine-associated neurotropic or viscerotropic disease in immunosuppressed patients such as those on golimumab.
How serious is the interaction between Golimumab and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the vaccine during golimumab therapy; advise against travel to endemic areas or provide a medical exemption letter when appropriate.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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