Drug interactions
Goserelin + Inotuzumab
Severity: Major
Goserelin and Inotuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin is associated with QT prolongation and goserelin may add a further effect. Concurrent use may increase the risk of torsades de pointes in patients with other risk factors.
What this interaction means in plain words
Goserelin and Inotuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain ECGs and electrolytes before starting and periodically during treatment. Correct electrolyte disturbances and consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Inotuzumab?
MediHelp rates the interaction as major. Goserelin and Inotuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotuzumab ozogamicin is associated with QT prolongation and goserelin may add a further effect. Concurrent use may increase the risk of torsades de pointes in patients with other risk factors.
How serious is the interaction between Goserelin and Inotuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs and electrolytes before starting and periodically during treatment. Correct electrolyte disturbances and consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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