Drug interactions
Goserelin + Lithium
Severity: Moderate
Goserelin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Goserelin, through androgen deprivation, can prolong the QT interval, and lithium may add to this effect. The concern is greatest in patients with heart disease or electrolyte disturbances.
What this interaction means in plain words
Goserelin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Consider baseline and periodic ECG monitoring and correct electrolyte abnormalities. Monitor lithium levels and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Lithium?
MediHelp rates the interaction as moderate. Goserelin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Goserelin, through androgen deprivation, can prolong the QT interval, and lithium may add to this effect. The concern is greatest in patients with heart disease or electrolyte disturbances.
How serious is the interaction between Goserelin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECG monitoring and correct electrolyte abnormalities. Monitor lithium levels and avoid adding other QT-prolonging drugs.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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