Drug interactions
Goserelin + Metformin-sitagliptin
Severity: Moderate
Goserelin and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with GnRH agonists such as goserelin can reduce insulin sensitivity and worsen glycemic control in men with diabetes. The effect develops over months and may require treatment adjustment.
What this interaction means in plain words
Goserelin and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Testosterone suppression increases insulin resistance and adiposity, opposing the action of antidiabetic drugs.
What to do
Monitor HbA1c and fasting glucose periodically during goserelin therapy and intensify antidiabetic treatment as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Goserelin and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with GnRH agonists such as goserelin can reduce insulin sensitivity and worsen glycemic control in men with diabetes. The effect develops over months and may require treatment adjustment.
How serious is the interaction between Goserelin and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HbA1c and fasting glucose periodically during goserelin therapy and intensify antidiabetic treatment as required.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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