Drug interactions
Goserelin + Metformin
Severity: Moderate
Goserelin and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with goserelin can worsen insulin resistance and glycemic control, which may blunt the effect of metformin in patients with diabetes. The effect emerges over months of therapy.
What this interaction means in plain words
Goserelin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, since hypogonadism increases insulin resistance and adiposity, opposing metformin's glucose-lowering effect.
What to do
Monitor fasting glucose and HbA1c after starting goserelin and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Metformin
Frequently asked questions
Can I take Goserelin with Metformin?
MediHelp rates the interaction as moderate. Goserelin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with goserelin can worsen insulin resistance and glycemic control, which may blunt the effect of metformin in patients with diabetes. The effect emerges over months of therapy.
How serious is the interaction between Goserelin and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting goserelin and adjust antidiabetic therapy as needed.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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