Drug interactions
Goserelin + Romidepsin
Severity: Moderate
Goserelin and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and romidepsin has also been associated with ECG changes including QT prolongation. Used together, the additive effect may raise the risk of torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Goserelin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Check baseline ECG and correct potassium and magnesium before and during romidepsin cycles. Repeat ECG if symptoms or additional QT-prolonging drugs are introduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Romidepsin?
MediHelp rates the interaction as moderate. Goserelin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and romidepsin has also been associated with ECG changes including QT prolongation. Used together, the additive effect may raise the risk of torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Goserelin and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before and during romidepsin cycles. Repeat ECG if symptoms or additional QT-prolonging drugs are introduced.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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