Drug interactions
Granisetron + Imipramine
Severity: Moderate
Granisetron and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can prolong the QT interval and widen the QRS, and granisetron adds a small QT effect. Serotonin syndrome has also been reported with 5-HT3 antagonists and serotonergic antidepressants.
What this interaction means in plain words
Granisetron and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Imipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and possible additive serotonergic effect.
What to do
Obtain a baseline ECG, correct electrolytes and monitor the QTc. Watch for serotonin toxicity and choose another antiemetic if risk factors accumulate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Granisetron with Imipramine?
MediHelp rates the interaction as moderate. Granisetron and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine can prolong the QT interval and widen the QRS, and granisetron adds a small QT effect. Serotonin syndrome has also been reported with 5-HT3 antagonists and serotonergic antidepressants.
How serious is the interaction between Granisetron and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct electrolytes and monitor the QTc. Watch for serotonin toxicity and choose another antiemetic if risk factors accumulate.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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