Drug interactions
Granisetron + Isocarboxazid
Severity: Major
Granisetron and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isocarboxazid is a nonselective irreversible MAO inhibitor, which markedly increases the risk of serotonin syndrome with serotonergic drugs. Serotonin syndrome has been reported with 5-HT3 antagonists, and the MAOI background makes the reaction harder to predict and potentially severe.
What this interaction means in plain words
Granisetron and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Isocarboxazid belongs to Central Nervous System.
Why it happens
Irreversible MAO inhibition increases serotonin availability, adding to the serotonergic effect of granisetron.
What to do
Prefer an antiemetic without serotonergic activity, such as a dopamine antagonist used cautiously. If used, monitor closely for serotonin syndrome and stop at the first signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Granisetron with Isocarboxazid?
MediHelp rates the interaction as major. Granisetron and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isocarboxazid is a nonselective irreversible MAO inhibitor, which markedly increases the risk of serotonin syndrome with serotonergic drugs. Serotonin syndrome has been reported with 5-HT3 antagonists, and the MAOI background makes the reaction harder to predict and potentially severe.
How serious is the interaction between Granisetron and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic without serotonergic activity, such as a dopamine antagonist used cautiously. If used, monitor closely for serotonin syndrome and stop at the first signs.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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