Drug interactions
Granisetron + Isoflurane
Severity: Moderate
Granisetron and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and granisetron adds a small effect. The combination is routine in anesthesia, but arrhythmia risk is higher with electrolyte disturbances or congenital long QT.
What this interaction means in plain words
Granisetron and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Correct potassium and magnesium before surgery and monitor the ECG during anesthesia. Avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Granisetron with Isoflurane?
MediHelp rates the interaction as moderate. Granisetron and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and granisetron adds a small effect. The combination is routine in anesthesia, but arrhythmia risk is higher with electrolyte disturbances or congenital long QT.
How serious is the interaction between Granisetron and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before surgery and monitor the ECG during anesthesia. Avoid the combination in congenital long QT syndrome.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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