Drug interactions
Granisetron + Ivosidenib
Severity: Major
Granisetron and Ivosidenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QT interval, and granisetron has a smaller but recognized QT effect. Combined use may add to the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease. The legacy note says QTc is decreased, which is wrong, since both drugs prolong it.
What this interaction means in plain words
Granisetron and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Ivosidenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects.
What to do
Prefer an antiemetic with less QT effect where possible. If combined, obtain a baseline and periodic ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Granisetron with Ivosidenib?
MediHelp rates the interaction as major. Granisetron and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib can prolong the QT interval, and granisetron has a smaller but recognized QT effect. Combined use may add to the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease. The legacy note says QTc is decreased, which is wrong, since both drugs prolong it.
How serious is the interaction between Granisetron and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with less QT effect where possible. If combined, obtain a baseline and periodic ECG and correct potassium and magnesium.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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