Drug interactions
Granisetron + Lefamulin
Severity: Moderate
Granisetron and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin prolongs the QT interval and granisetron can do so as well. Taking both together raises the possibility of additive QT prolongation and ventricular arrhythmia, especially in patients with other risk factors.
What this interaction means in plain words
Granisetron and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Monitor the ECG and correct hypokalemia and hypomagnesemia. Consider an alternative antiemetic if the patient has baseline QT prolongation or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Granisetron with Lefamulin?
MediHelp rates the interaction as moderate. Granisetron and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin prolongs the QT interval and granisetron can do so as well. Taking both together raises the possibility of additive QT prolongation and ventricular arrhythmia, especially in patients with other risk factors.
How serious is the interaction between Granisetron and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and correct hypokalemia and hypomagnesemia. Consider an alternative antiemetic if the patient has baseline QT prolongation or other risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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