Drug interactions
Granisetron + Pasireotide
Severity: Moderate
Granisetron and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong QT and cause bradycardia, and granisetron can add a small QT effect. Together they may raise the risk of torsade de pointes, particularly with hypokalemia or bradycardia.
What this interaction means in plain words
Granisetron and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Pasireotide belongs to Endocrine.
Why it happens
Additive QT prolongation, with pasireotide-related bradycardia further increasing susceptibility.
What to do
Get a baseline ECG and correct potassium and magnesium. Repeat ECG monitoring when starting the combination in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Granisetron with Pasireotide?
MediHelp rates the interaction as moderate. Granisetron and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong QT and cause bradycardia, and granisetron can add a small QT effect. Together they may raise the risk of torsade de pointes, particularly with hypokalemia or bradycardia.
How serious is the interaction between Granisetron and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Get a baseline ECG and correct potassium and magnesium. Repeat ECG monitoring when starting the combination in patients with cardiac risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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