Drug interactions
Granisetron + Pazopanib
Severity: Moderate
Granisetron and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes, and granisetron can also modestly prolong the QT interval. Combined use may add to arrhythmia risk, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Granisetron and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarisation through effects on cardiac ion channels.
What to do
Correct potassium and magnesium before and during therapy and obtain a baseline and periodic ECG. Prefer an antiemetic with less QT effect if the patient has additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Granisetron with Pazopanib?
MediHelp rates the interaction as moderate. Granisetron and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is associated with QT prolongation and torsades de pointes, and granisetron can also modestly prolong the QT interval. Combined use may add to arrhythmia risk, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Granisetron and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy and obtain a baseline and periodic ECG. Prefer an antiemetic with less QT effect if the patient has additional risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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