Drug interactions
Granisetron + Rasagiline
Severity: Moderate
Granisetron and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a selective MAO-B inhibitor, and serotonin syndrome has been reported with serotonergic drugs given alongside MAO inhibitors. Granisetron has only weak serotonergic liability, so the risk is low but not negligible.
What this interaction means in plain words
Granisetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Rasagiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect; the mechanism is not firmly established for 5-HT3 antagonists.
What to do
Granisetron can be used when needed at usual doses. Monitor for signs of serotonin toxicity such as tremor, clonus, agitation and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Granisetron with Rasagiline?
MediHelp rates the interaction as moderate. Granisetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a selective MAO-B inhibitor, and serotonin syndrome has been reported with serotonergic drugs given alongside MAO inhibitors. Granisetron has only weak serotonergic liability, so the risk is low but not negligible.
How serious is the interaction between Granisetron and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Granisetron can be used when needed at usual doses. Monitor for signs of serotonin toxicity such as tremor, clonus, agitation and hyperthermia.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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