Drug interactions
Granisetron + Selegiline
Severity: Moderate
Granisetron and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline inhibits MAO and can contribute to serotonin toxicity with other serotonergic drugs. Granisetron has been associated with rare serotonin syndrome reports, so the combination carries a low but real risk.
What this interaction means in plain words
Granisetron and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Selegiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect with MAO inhibition.
What to do
Use only when needed and monitor for signs of serotonin syndrome after initiation. Stop granisetron and treat supportively if features develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Granisetron with Selegiline?
MediHelp rates the interaction as moderate. Granisetron and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline inhibits MAO and can contribute to serotonin toxicity with other serotonergic drugs. Granisetron has been associated with rare serotonin syndrome reports, so the combination carries a low but real risk.
How serious is the interaction between Granisetron and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when needed and monitor for signs of serotonin syndrome after initiation. Stop granisetron and treat supportively if features develop.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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