Drug interactions
Granisetron + Vandetanib
Severity: Major
Granisetron and Vandetanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death, and its labeling advises avoiding other QT-prolonging drugs. Granisetron adds to this risk.
What this interaction means in plain words
Granisetron and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Vandetanib belongs to Oncology.
Why it happens
Additive prolongation of the QT interval.
What to do
Avoid the combination and choose an antiemetic with no meaningful QT effect. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Granisetron with Vandetanib?
MediHelp rates the interaction as major. Granisetron and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death, and its labeling advises avoiding other QT-prolonging drugs. Granisetron adds to this risk.
How serious is the interaction between Granisetron and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiemetic with no meaningful QT effect. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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