Drug interactions
Grapefruit + Ixazomib
Severity: Minor
Grapefruit and Ixazomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4, but even strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. A relevant interaction is not expected.
What this interaction means in plain words
Grapefruit and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Grapefruit components inhibit intestinal CYP3A4, which has little influence on ixazomib clearance.
What to do
No dietary restriction is required specifically for this interaction; monitor routinely for ixazomib toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Grapefruit with Ixazomib?
MediHelp rates the interaction as minor. Grapefruit and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4, but even strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. A relevant interaction is not expected.
How serious is the interaction between Grapefruit and Ixazomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dietary restriction is required specifically for this interaction; monitor routinely for ixazomib toxicity.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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