Drug interactions
Griseofulvin + Iloperidone
Severity: Moderate
Griseofulvin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is cleared by CYP3A4 and CYP2D6. Griseofulvin may reduce its plasma concentration, potentially decreasing antipsychotic effect.
What this interaction means in plain words
Griseofulvin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Iloperidone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by griseofulvin increases iloperidone clearance.
What to do
Monitor for loss of psychiatric symptom control during and after griseofulvin therapy. Adjust the iloperidone dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Griseofulvin with Iloperidone?
MediHelp rates the interaction as moderate. Griseofulvin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is cleared by CYP3A4 and CYP2D6. Griseofulvin may reduce its plasma concentration, potentially decreasing antipsychotic effect.
How serious is the interaction between Griseofulvin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control during and after griseofulvin therapy. Adjust the iloperidone dose according to clinical response.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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